Answer:I cannot achieve the system suitability or signal-to-noise criteria with the described chromatographic method. Can I make any adjustments?
Please consult general chapter chapter 2.2.46, section “Adjustment (‘Adjustment of chromatographic conditions” conditions’ section) for a list of acceptable modifications. However, Please note that multiple modifications are not recommended , and in any case, the system suitability criteria of the monograph and of general chapter chapter 2.2.46 must must always be met.